Impotence is also called erectile dysfunction. Erectile dysfunction caused by chronic renal failure can be treated by medication, adopting good living habits, device therapy and kidney transplantation. 1. Medication: Common medications include sildenafil, which is a phosphodiesterase 5 inhibitor that increases blood flow to the penis by enhancing the effect of nitric oxide on smooth muscle, thus prompting an erection. Adverse reactions include flushing, angina, asthma, etc. It is contraindicated in patients with severe hepatic impairment, allergy, and recent stroke. 2. General treatment and psychological treatment: bad habits can aggravate erectile dysfunction, quit smoking and drinking can help erectile dysfunction treatment. Some patients with erectile dysfunction caused by psychological factors can consult a psychiatrist for appropriate psychological counseling. 3. Instrumental treatment: use vacuum negative pressure device to make the penis reach the state of erection, improve blood circulation and relieve erectile dysfunction. 4. Dialysis or kidney transplantation: Chronic renal failure can lead to testicular atrophy in severe cases, resulting in a decrease in testosterone level and causing erectile dysfunction. Therefore, dialysis or kidney transplantation for chronic renal failure can improve the symptoms of erectile dysfunction. Patients with chronic renal failure impotence should go to the hospital in time and choose the appropriate treatment under the advice and guidance of doctors.