Blood pressure has been at 160mmHg can not come down, may be related to antihypertensive drugs take poorly, emotional fluctuations or secondary hypertension and other reasons. Failure to take antihypertensive drugs regularly or irrational selection of antihypertensive drugs and other reasons, need to consult a doctor in a timely manner, according to the doctor’s instructions to adjust antihypertensive drugs, timely control of blood pressure. During the period of taking antihypertensive drugs, exertion and emotional excitement may also affect the therapeutic effect of antihypertensive drugs, so it is necessary to adjust the emotion and avoid excessive exertion. For patients with secondary hypertension caused by renal artery stenosis, pheochromocytoma, etc., the efficacy of taking conventional antihypertensive drugs is not good, therefore, interventional or surgical treatment is needed to treat the cause. For patients whose blood pressure remains high after taking medication, it is recommended to consult a doctor in time to clarify the cause of the disease and then treat the cause and symptoms.