The soles of the feet with small blisters and pain need to be based on the cause of the symptomatic treatment, the common cause of blister tinea pedis, palmoplantar pustulosis, and so on, the general use of medication method. 1. blistering tinea pedis: blistering tinea pedis is a foot skin disease caused by dermatophyte infection, often occurring on the soles of the feet, between the toes of the skin, manifested as blisters on the surface of the skin, accompanied by intense itching, and sometimes pain. Topical antifungal drugs, such as clotrimazole ointment, Butenafine hydrochloride cream, etc., can be used, and severe cases can be combined with oral antifungal drugs, such as itraconazole, terbinafine. 2. Palmoplantar pustulosis: palmoplantar pustulosis may be related to local infection, metal allergy, heredity, drugs and other factors, mainly manifested in the palms of the hands or soles of the feet aseptic pustules, often accompanied by itching, burning sensation and pain symptoms. Local topical glucocorticoid drugs, such as halometasone ointment, mometasone furoate cream, etc., can also be oral retinoids, such as avitaminic acid, oral immunosuppressants, such as cyclosporine, methotrexate, etc.. All of the above drugs have adverse reactions and are recommended to be used under medical supervision. Small blisters on the soles of the feet may also have other causes, it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease to give targeted treatment.