There are many causes of ankle joint effusion, including traumatic arthritis, gouty arthritis, rheumatoid arthritis, osteoarthritis, and arthritis caused by infections. Different causes of the disease can be treated in different ways, and general treatment, physiotherapy, medication, and surgical treatment should be given according to the cause of the disease. Traumatic arthritis: need to reduce ankle activities, can be given local hot packs, oral or topical diclofenac sodium and other non-steroidal anti-inflammatory drugs, serious damage to the joints, conservative treatment is ineffective to consider surgical treatment, such as arthroscopic cleanup. Gouty arthritis: usually low purine diet, the acute period to rest, relief period can be appropriate exercise, acute period can be appropriate cold compresses to relieve pain. Acute period can take colchicine treatment, while the remission period can be given to allopurinol and other drugs to lower uric acid treatment. Rheumatoid arthritis: non-steroidal anti-inflammatory drugs such as ibuprofen can be given to treat, and if necessary, prednisone and other glucocorticoid drugs can also be given to treat. Osteoarthritis: belongs to the ankle joint degenerative changes. It is necessary to pay attention to rest, avoid weight-bearing and strenuous exercise, local hot compresses can be given, which is conducive to the absorption of fluid, can be given non-steroidal anti-inflammatory drugs such as diclofenac sodium treatment, the ankle can also be injected with sodium vitrate treatment. Infectious arthritis: bacterial infection, need to give amoxicillin and other antibacterial drugs, tuberculosis mycobacteria infection can be given rifampicin, isoniazid and other anti-tuberculosis drugs. It is recommended that patients go to the hospital, improve the examination, clear the cause of the disease, the drugs need to be used under the guidance of a professional physician.