There are many diseases that you should beware of, such as gastric diseases, pancreatic diseases, heart diseases, etc. 1. Gastric diseases: such as gastric ulcer, acute gastritis, chronic gastritis, gastric cancer, gastroesophageal reflux disease, etc., can cause pain in the middle of the stomach. 2. Pancreatic diseases: such as acute pancreatitis, chronic pancreatitis, pancreatic cancer, etc., can also cause hidden pain in the middle of the stomach. 3. Heart disease: angina pectoris, myocardial infarction, pericarditis, etc., can also cause pain in the middle of the stomach. There are many other causes of pain in the upper center of the stomach, which should be taken seriously, consult a doctor in a timely manner to identify the cause of the disease, and follow the doctor’s instructions for further treatment or therapy.