There is no fastest way to stop toothache, different types of toothache pain relief methods are different, caries need filling treatment; pulpitis and apical periodontitis need root canal treatment; wisdom tooth pericoronitis need anti-inflammatory treatment; periodontal abscess need periodontal sequence treatment. 1. Caries: The main manifestation is pain after hot or cold water enters the cavity, and the pain disappears immediately after the stimulus is removed. It can be cured by directly removing the decayed tissue and filling treatment. 2. Pulpitis and periapical inflammation: the main manifestation is pain after hot and cold stimulation, and the pain continues after the stimulation is removed. Pulpitis also has the symptoms of night pain and pain that can not be localized; periapical inflammation has the symptoms of discomfort of biting objects. Root canal treatment is needed to stop pain, remove the infected pulp and dentin wall, and then filling. 3. Wisdom tooth pericoronitis: mainly manifested as swelling and pain, accompanied by facial swelling and limited mouth opening in severe cases. It is recommended to take oral cefuroxime tablets, amoxicillin capsules, metronidazole tablets and other antibiotics to relieve pain, and in severe cases, intravenous anti-inflammatory treatment, and remove the wisdom teeth after the symptoms are relieved. 4. Periodontal abscess: mainly manifested as tooth swelling, throbbing pain, teeth may appear loose. Acute oral cefuroxime tablets, amoxicillin capsules, metronidazole tablets and other anti-infective treatment, after the symptoms are relieved periodontal sequence treatment, if necessary, extraction. It is recommended that patients with toothache go to the stomatology department of the regular hospital, different causes of different treatment methods, do not listen to prescriptions, so as not to delay the condition. All of the above drugs should be used in accordance with medical advice.