Malignant melanoma has a predominant incidence among Caucasians in Europe and the United States, but in recent years, we have encountered more and more of them in the clinic, and some of them come to the hospital at a late stage and lose the best treatment time. If the tumor is deeper than 1mm, it is recommended to do prophylactic regional lymph node dissection to prevent distant metastasis; 4, for patients whose tumor has metastasized to more than one regional lymph node, it is recommended to do immunotherapy, interferon alpha-2b 5 million units, 2-3 times/intramuscular or subcutaneous injection; 5, patients with advanced disease can do traditional Chinese medicine. The treatment not recommended: 1, the scope of excision is not enough, just do biopsy; to do surgery, we have to install conventional expanded excision, repair the trauma; 2, the regional lymph nodes have metastasized patients, just remove with lesions, not to regional lymph node clearance; this is better not to do, direct immunotherapy; 3, melanoma of the limbs, not necessarily is amputation There are many ways to repair the trauma, even very large trauma, and must reduce amputation; 4. chemotherapy and radiation therapy are not recommended for patients with advanced disease, because melanoma is not sensitive to these treatments.