With the advancement of stem cell research, it provides a brand new way for human to understand the occurrence of diseases and develop new therapeutic approaches. Stem cells are a class of cells with self-renewal and multi-directional differentiation potential. It not only has the regenerative and repairing effects of tissue cells, but also has powerful immunomodulatory functions. It is these two functions of stem cells that create a new model of cell regeneration therapy for premature ovarian failure. I. Experimental report In 1991, McElreaveyKD reported for the first time that umbilical cord mesenchymal stem cells were isolated and cultured from human umbilical cord wartong glue. The umbilical cord has similar biological characteristics to bone marrow, however, it is superior to bone marrow source in terms of proliferation and differentiation ability, and the secretion of cytokines is also different between the two. The mechanism of stem cell repair in ovaries 1. Stem cells can localize, expand, self-renew and survive for a long time in the ovaries. 2. Stem cells colonize the damaged area and differentiate, such as ovarian epithelial cells and follicular cells, partially compensating or replacing them to repair their functions. 3.Secrete a variety of cytokines to protect germ cells from apoptosis and DNA damage, promote the renewal of germ stem cells and restore ovarian function. 4.Through immunomodulatory effect, it inhibits the body’s immune response and promotes the self-repair of damaged tissues. 5.Protects damaged ovaries by repairing ovarian interstitium and preventing ovarian fibrosis. 6.Directly reach the damaged area and differentiate into some vascular endothelial cells to provide nutritional support 7.Improve ovarian follicle stimulating hormone microenvironment, restore the function of damaged ovaries and improve reproductive health 8.Prevent follicular atresia, promote follicular renewal and enhance reproductive capacity 3.Effects of stem cell ovarian repair: 1.Prevent premature aging, delay menopause Regulate the balance of endocrine system, improve the collective immune function, prolong menstruation, make 2.Keep the skin young Through ovarian maintenance, it can make the skin delicate and smooth, white and red, restore toughness and elasticity, fundamentally reduce dryness, wrinkles and pigmentation 3.Regulate female system function in all aspects Enhance ovarian function, regulate sex hormone secretion, reduce estrogen-related diseases such as cardiovascular disease, uterine fibroids, urinary system inflammation and other problems 4.Maintain female elegance Premature ovarian failure is one of the biggest threats to the health of female reproductive system, and mesenchymal stem cells have achieved amazing results in the preclinical treatment of premature ovarian failure. It is believed that stem cells will bring more surprises to human beings in the near future.