Osteoblastoma of knee joint is mainly treated by surgery. Smaller tumors can be treated by lesion excision with inactivation, while severe cases can be treated by segmental resection or prosthesis implantation. Knee osteoblastoma is mainly because osteoblastoma involves the knee joint, although osteoblastoma belongs to the junctional tumor, there is a tendency of malignant transformation, so it is mainly treated by surgery. When the tumor is confined to the extra-articular area and is small, it can be treated by lesion excision with inactivation, followed by autologous or allogeneic bone and bone cement implantation according to the specific situation. For larger tumors that interfere with knee function, knee prosthesis implantation, such as a hinged knee replacement, or segmental resection may be considered. If the diagnosis of osteoblastoma of the knee is confirmed, the treatment should be standardized in a timely manner under the guidance of a doctor.