Liver surface roughness combined with splenomegaly is usually considered to be caused by chronic hepatitis, cirrhosis and other substantial liver lesions. 1. Causes of liver surface roughness: (1) Chronic hepatitis: chronic liver injury can be caused by long-term alcohol consumption and viral infection, which can lead to hepatitis. (2) Cirrhosis: due to such as viral hepatitis, alcoholic hepatitis and other persistent, triggered cirrhosis, resulting in irreversible changes in the liver. (3) Drug poisoning: due to the presence of liver-damaging substances in drugs such as pyrrolizidine alkaloids, etc. can damage the liver, which in turn triggers liver fibrosis. (2) Causes of splenomegaly: due to different degrees of necrosis and fibrosis of liver tissue, cirrhosis occurs, which causes portal hypertension, which leads to increased pressure in the splenic vein, further causing the spleen to become enlarged. If you find rough liver surface combined with splenomegaly, you need to go to the hospital in time to get a clear diagnosis and treatment plan, and use medication under the guidance of the doctor to avoid self-medication.