Severe mitral regurgitation requires surgical treatment based on the primary disease and attention to daily care. Mitral regurgitation is associated with rheumatic heart disease, mitral valve prolapse syndrome and infective endocarditis, etc. In case of severe mitral regurgitation, echocardiography may show a jet area >8cm², and a regurgitant flow rate of >60 ml per beat, with a regurgitant flow fraction of more than 50%. In this case, medical treatment is relatively ineffective and valve replacement is recommended, as well as anticoagulation with warfarin as prescribed by the doctor. In addition, daily attention should be paid to diet, limiting sodium intake, spicy and greasy food is not recommended. Do not engage in heavy physical labor and avoid strenuous exercise.