The yellowing of the middle and back of the tongue is considered to be related to yin deficiency and internal heat, dampness and heat in the spleen and stomach, etc. It can be treated with Zhi Bai Di Huang Wan and Gan Gan Disinfecting Pill as prescribed by the doctor. 1. Yin deficiency and internal heat: Yin deficiency and internal heat can cause yellowing of the middle and back of the tongue in some patients, and the clinical treatment principle is to nourish Yin and clear heat. Usually, patients can follow the doctor’s instructions to use Zhi Bai Di Huang Wan, Dai Tonic Yin Wan, He Che Da Zao Wan and other proprietary Chinese medicines for treatment. In addition to medication, the patient also acupuncture Yongquan point, Taixi point, kidney point and other acupuncture points to regulate the body. Zhi Bai Di Huang Wan nourishes yin and reduces fire, and is used for yin deficiency and fire, hot flashes and night sweating (abnormal sweating after going to sleep and stopping after waking up), dry mouth and sore throat, tinnitus and spermatorrhea, and short and red urination (small amount of urination with dark yellow color). Pregnant women should take it with caution. It is not suitable for patients with deficiency-cold syndrome, and should not be taken at the same time with cold and flu medicines. 2. Damp-heat in the spleen and stomach: If it is caused by damp-heat in the spleen and stomach, the main treatment principle is to clear heat and relieve dampness. Usually, patients can follow the doctor’s instructions to regulate with Chinese medicines such as Ganlu Sterilizing Pill and Ge Ge Gen Scutellariae Lian Tablet. Some patients may also seek medical advice and acupuncture at the acupoints of the middle epigastric region, the Neiguan and the foot Sanli. Ganlu Disinfecting Pill is aromatic, clearing heat and removing toxins, and is used for summer-dampness accumulation, body heat and limb soreness, chest tightness and abdominal distension, and urine redness and jaundice. The adverse reactions of the above drugs are not clear. It is recommended that people with yellowing of the middle and back of the tongue should consult a doctor in time, and take treatment based on evidence in combination with systemic symptoms, and should not use drugs or prescriptions indiscriminately. Pay attention to the rationality of diet during the use of medication, avoiding the intake of cold, spicy and stimulating food.