A painless electrogastroscopy is actually a short, rapid-acting sedative and anesthetic given intravenously so that the patient is unaware of the examination. The procedure is very short and the patient can be awakened within a few minutes after the examination. Painless gastroscopy has the following advantages: ① elimination of patient’s nervousness and anxiety, and improvement of tolerance to the examination; ② no memory and painful feeling of the whole examination process; ③ reduction of gastrointestinal peristalsis, which facilitates the detection of microscopic lesions; ④ reduction of the occurrence of mechanical injuries caused by unconscious agitation of patients due to pain. Painless gastro (or enteroscopy) also involves certain risks due to the use of some sedatives and anesthetics, but much less than surgical anesthesia. However, since the doses of these drugs are very small and are administered by skilled professional anesthesiologists and performed under the close supervision of multi-functional monitors and anesthesia machines, and the examination room is specially equipped with corresponding emergency equipment and drugs, the possibility of complications is extremely small.