Chronic pelvic inflammatory disease (PID) has an impact on IVF and can reduce the success rate, so appropriate intervention should be made before proceeding with IVF. Chronic pelvic inflammatory disease includes endometritis, pelvic connective tissue inflammation, and salpingitis. Among them, endometritis will destroy the functional layer of the endometrium, and in severe cases, it will cause thinning of the endometrium and adhesions, which will affect embryo transfer and prevent the blastocysts from implanting, thus causing IVF failure. Chronic pelvic inflammatory disease can cause tubal obstruction and fluid accumulation. If the fluid accumulation is high, it will flow back into the uterine cavity, thus affecting the tolerance of the endometrium or causing endometrial damage, and the fluid accumulation can also wash away the blastocysts, resulting in a decrease in the implantation rate. When chronic pelvic inflammatory disease is diagnosed, appropriate intervention for inflammation should be made before IVF, and the IVF cycle should be entered when the inflammation is under control and the intrauterine environment is ideal, which can improve the success rate.