Disadvantages and indications of radiation therapy for pituitary adenoma (Gamma Knife): The pituitary gland is an important endocrine organ in the body, and the hormones it secretes play an important role in maintaining the body’s function. Radiation therapy, including gamma knife, is very likely to lead to delayed pituitary hypofunction, and the vast majority of them are permanent and irrecoverable, which seriously affects the quality of life of patients, so the international use of gamma knife as the third-line treatment for pituitary tumors should be carefully selected. In addition, some pituitary tumors compress the optic nerve and optic cross, which is a contraindication to gamma knife treatment, because the inevitable edema of the tumor after radiation therapy will further aggravate the visual compression.