After eating isosorbide mononitrate extended-release tablets, it is best not to take the service sildenafil, because in general these two drugs can not be combined. Isosorbide mononitrate extended-release tablets belong to the vasodilator class of drugs, mainly used for coronary heart disease, angina pectoris and other diseases of long-term treatment and prevention; the half-life of the drug is 12 hours, and the complete metabolism in the body takes about 24 hours. Sildenafil is mainly used for the treatment of erectile dysfunction and other diseases in men, prohibited and nitrate drugs in combination, to avoid the enhancement of nitrate antihypertensive effect; taking isosorbide mononitrate extended-release tablets, although the drug has been completely metabolized in 24 hours or so, but it is best not to take to take sildenafil. Isosorbide mononitrate extended-release tablets may appear after taking nausea, vomiting, dizziness and other adverse reactions, for acute circulatory failure, cardiogenic shock, severe hypotension or anemia, increased intracranial pressure is prohibited; need to follow the doctor’s instructions in the process of using the drug to avoid overdose of the drug appeared hypotension, tachycardia and other discomforts, pregnant women and other special groups need to be in the guidance of the doctor to use the drug. Sildenafil may appear after the use of facial edema, angina, vomiting and other discomforts, for those who are taking nitrates, heart failure, coronary heart disease, unstable angina is prohibited; after the use of the drug in the sexual life of angina, dizziness and other discomforts, you need to immediately stop having sex, and go to the hospital in a timely manner, the special people need to be guided by a doctor to use the drug. The above medication should be used under the guidance of a doctor, avoid self-medication, so as not to cause adverse consequences.