Nearly 1,000 mutant strains of neocoronaviruses have been identified worldwide. Neocoronaviruses are RNA viruses, and the viral RNA is mutated during replication, resulting in the emergence of nearly 1,000 mutant strains. There are mainly 5 kinds of mutated new coronaviruses, which are α, β, γ, δ and Omicron mutated strains, which are more harmful to human beings and have stronger infectious power. 1. α mutant strains: There are more than ten kinds of mutations, and the transmissibility has been strengthened. One of the mutations is the amino acid deletion of the spiny protein, and the deletion will make it difficult to increase the molecular detection of some neocoronaviruses, which may increase the rate of leakage diagnosis. 2. β variant: The β variant has increased virulence as well as transmissibility. 3. γ variant: This variant strain is further more transmissible than the previous two, due to three mutations in the receptor-binding domain of the spiking protein. 4. δ variant: This new coronavirus variant is characterized by increased transmissibility and virulence, which significantly increases the probability of severe illness after infection. 5. Omicron mutant strain: Omicron infection is further shortened by about 4 days compared to the delta mutant strain, and the transmission capacity is roughly twice that of the delta mutant strain, which has a stronger transmission capacity. In order to effectively reduce the chances of infection, personal hygiene should be paid attention to in normal times, go out to take good protective measures, and there is no contraindication to the need for people to be vaccinated with the new coronary vaccine. [Tip] In this article, “new coronavirus pneumonia” and “new coronavirus pneumonia” have been renamed to “new coronavirus infection” on December 26, 2022, as announced by the National Health Commission.