If the patient’s vitreous nodules are caused by bacteria, viruses, or atypical pathogenic bacteria, they may disappear on their own with treatment or over time. If the patient has a benign nodule, it is also possible that the nodule may persist for a long time and that the dynamic changes will not be significant later in life. In the rare case of a ground glass nodule, there is a possibility that it may be a malignant nodule that may develop in the short term. When a patient presents with a ground glass nodule, a comprehensive analysis is performed and relevant tests are refined. The management of different nodules is different. Nodules caused by pathogenic bacteria require appropriate anti-infective, antiviral, and anti-mycoplasma treatment. Benign nodules are reviewed regularly, and malignant nodules may be considered for surgery, radiotherapy, chemotherapy, or targeted cellular drug therapy.