When side effects of Amphotericin B appear, they need to be treated in different ways depending on the severity of the side effects. Since it is difficult to eliminate the side effects after they appear, you need to be careful with the medication before choosing the treatment. Side effects of Amphotericin B mainly include fever, chills, headache, nausea, vomiting, and drop in blood pressure during titration, followed by renal impairment, hypokalemia, hepatotoxicity, and hematologic toxicity. When serious side effects occur during treatment with amphotericin B, the drug should be discontinued and symptomatic treatment should be given. When the side effects are mild, symptomatic treatment can be carried out. People with liver or kidney insufficiency need to be cautious. Regular monitoring of liver function, kidney function, potassium, ECG, and routine urinalysis should be performed during the medication period. In order to ensure the safety of the medication, it is important to strictly follow the doctor’s instructions.