Epalrestat and methylcobalamin can be used in combination to improve diabetic peripheral neuropathy. Epalrestat is an aldose reductase inhibitor, long-term treatment can effectively improve the symptoms of diabetic neuropathy, delay disease progression, mainly prohibited for drug allergy. Mecobalamin is active vitamin B₁₂, can repair damaged nerve cells, improve nerve conduction velocity, can significantly improve diabetic neuropathy, prohibited for drug allergy. According to research and clinical application, Epalrestat combined with methylcobalamin is superior to monotherapy in the treatment of diabetic neuropathy. In addition to the pharmacologic treatment of diabetic peripheral neuropathy, effective control of blood glucose levels can also slow the progression of diabetic neuropathy and other complications. All of the above drugs are prescription drugs, need to be used under the guidance of a doctor, the general course of treatment needs to be at least 3 months in order to have a significant effect, to avoid stopping the drug arbitrarily.