Pediatric septicemia is caused by pathogenic bacteria, including bacteria and fungi, which enter the human blood circulation, grow and multiply, and cause systemic poisoning. Pediatric septicemia has a high incidence and can be caused by infections in any part of the body. Due to the incomplete immune function of children and their generally weak resistance, they are easily infected by pathogenic bacteria, fungi and other pathogens, which leads to the occurrence of pediatric septicemia. It should be noted that if these pathogenic bacteria are not well controlled, they can enter the blood circulation with the blood flow and produce some toxins or other metabolites, which gradually affect the whole body, thus triggering a series of systemic inflammatory reactions, such as persistent high fever, depression, vomiting, diarrhea, etc., which may lead to severe infectious shock and multi-organ failure, or even life-threatening. The development of pediatric sepsis is an extremely complex process, must pay attention to and seize the opportunity of early treatment, parents need to be reminded not to take their children’s mild infections lightly, but to remain vigilant at all times, and it is recommended to consult a doctor in a timely manner, so as to avoid delay in treatment.