The main reasons for frequent hand pain and weakness are related to bone and joint diseases, neurological diseases, muscle and soft tissue injuries or overwork. 1. Osteoarthritic diseases: If there are joint diseases in the hand area, such as inflammation or degenerative diseases of wrist joints, the symptoms of hand pain and weakness will occur frequently. 2. Neurological diseases: If there is peripheral nerve injury or brain injury in the upper limbs, it can trigger nerve dysfunction, which often leads to the manifestation of hand pain and weakness. 3. Muscle and soft tissue injury: hand muscle and soft tissue injury, easy to directly produce hand pain and weakness symptoms, and even accompanied by the swelling of the performance. 4. Excessive fatigue: frequent use of the hands to lift heavy objects or strenuous exercise, easy to cause excessive fatigue of the hand muscles, resulting in hand pain and weakness. If the symptoms persist for a longer period of time, it is easy to affect the function of the movement, need to be targeted treatment under the guidance of a professional physician. Frequent hand pain and weakness, should be timely to the orthopedic examination, clear cause and active treatment.