High ALP alkaline phosphatase may be a physiologic increase or a pathologic increase caused by rickets, cirrhosis and other diseases. 1. Physiological increase: children are physiological bone development, alkaline phosphatase activity can be 1 to 2 times higher than normal; adolescents in the growth period, as well as pregnant women can cause alkaline phosphatase elevation. 2. Pathologic increase: (1) bone disease: such as rickets, osteochondrosis, bone malignant tumor, malignant tumor bone metastasis, etc., the destruction of bone quality so that the alkaline phosphatase contained in bone cells is released into the blood, causing elevated serum alkaline phosphatase. (2) Hepatobiliary diseases: such as extrahepatic bile duct obstruction, hepatocellular carcinoma, cirrhosis, capillary cholangiohepatitis, etc., resulting in damage to hepatocytes and the release of alkaline phosphatase, causing pathologic elevation of alkaline phosphatase. (3) Other diseases; such as hyperparathyroidism, which promotes the action of osteoclasts, causing the release of bone calcium, bone phosphorus, and alkaline phosphatase into the blood, causing an increase in alkaline phosphatase. ALP alkaline phosphatase high, the cause is more complex, it is recommended to consult a doctor in order to clarify the diagnosis, under the guidance of the doctor for targeted treatment.