Sedentary buttock pain and lateral thigh pain may be due to sedentary, gravity compression and other physiological factors, but also may be caused by lumbar disc herniation, pyriformis syndrome and other pathological factors. 1. Physiological factors: due to sedentary or gravity pressure, can lead to the strain of the buttock muscles and sciatic nerve transient compression, can cause pain and numbness of the buttock and lateral thigh muscles. Usually, it can be gradually relieved by changing the posture, moving the limbs and taking sufficient rest. 2. Herniated lumbar intervertebral disc: patients with herniated lumbar intervertebral disc, after sitting for a long time, it will lead to the increase of lumbar force and aggravate the nerve compression symptoms, which will lead to pain in the buttocks, perineum and lateral thighs, and at the same time, accompanied by a sense of numbness. 3. Piriformis syndrome: due to chronic strain injury can lead to sciatic nerve compression in the buttocks, causing pain in the buttocks and radiating pain in the lower limbs, accompanied by numbness, long-term sedentary can also aggravate the pain symptoms. Sedentary buttock pain thigh pain, there may be other causes, such as fasciitis, etc., it is recommended to consult a doctor in a timely manner, a clear diagnosis, for treatment.