Toe ulcers in uremia patients may be caused by the patient’s own disease, or due to diabetic foot, tinea pedis and other causes. 1. Uremia: Uremia is the common ending of the development of various advanced kidney diseases. As metabolic wastes and toxins are hoarded in the body, it can cause itchy skin and toe ulcers. 2. Diabetic foot: a general term for a series of clinical manifestations of the foot caused by peripheral neuropathy and vascular lesions in diabetic patients. Uremia combined with diabetes, patients can appear foot sensory abnormalities, foot deformity, foot pain and walking difficulties and other symptoms, serious patients can appear ulceration, infection and gangrene, and even need amputation. 3. Tinea pedis: patients with uremia have low immunity and are easily infected with pathogenic bacteria. The common pathogenic bacteria that cause foot ulcers are red trichophyton, trichophyton suis, etc. When there is between rubbing erosion type of tinea pedis, the skin lesions are manifested as the skin between the toes is wet, impregnated with whitish, and the whitish epidermis can be seen underneath the reddish surface of the vesicles, i.e., the ulcers. It is recommended that patients with uremic toe ulcers go to the hospital in a timely manner, follow the doctor’s instructions for treatment, to avoid delaying the condition.