Generic name of Depakene is Sodium Valproate Extended-Release Tablets, and this medication enhances the blood levels of carbamazepine. If you want to use the medication at the same time, you must follow your doctor’s instructions strictly. Both sodium valproate extended-release tablets and carbamazepine are antiepileptic drugs. When these two drugs are used together, Sodium Valproate Extended-Release Tablets can increase the blood concentration of the active metabolite of carbamazepine, which can cause an overdose reaction. At the same time, carbamazepine has an inducing effect on hepatic metabolism, and this effect will cause the blood concentration of sodium valproate extended-release tablets to decrease. Sodium valproate extended-release tablets are indicated for generalized epilepsy, as well as simple partial seizures, complex partial seizures, partial secondary generalized seizures and other partial epilepsy, mania. Side effects such as nausea stomach pain and diarrhea are occasionally seen with this drug. It is contraindicated in patients with acute and chronic hepatitis, hypersensitivity to this drug, urea cycle disorders, history or family history of severe hepatitis. Carbamazepine can be used for generalized tonic-clonic seizures, complex partial seizures, mixed seizures, trigeminal neuralgia and glossopharyngeal neuralgia seizures, restless leg syndrome, central partial diabetes insipidus, and many other diseases. Side effects such as blurred vision, nystagmus and diplopia are more common with this drug. It is contraindicated in people who are allergic to this drug and in those with severe hepatic insufficiency. If you want to use sodium valproate extended-release tablets and carbamazepine at the same time, you must strictly follow the doctor’s instructions for clinical drug monitoring and timely adjustment of the dose.