Some patients may experience diarrhea after taking quadruple therapy. Quadruple therapy is clinically used for the eradication of Helicobacter pylori, which includes two antibiotics + bismuth + proton pump inhibitors. Antibiotics commonly used include amoxicillin, clarithromycin, etc., all of which have adverse reactions that can lead to diarrhea and abdominal pain. Therefore, during or after quadruple therapy treatment, some patients may experience diarrhea, which is a common adverse reaction of the drug, such as diarrhea symptoms are not serious, usually after stopping the drug can be gradually relieved. If diarrhea occurs for a long time or repeatedly after taking quadruple therapy, it is necessary to be alert to whether the intestinal flora imbalance occurs. You can follow the doctor’s instructions to take intestinal probiotics to regulate, clinically more commonly used Bacillus licheniformis, Bifidobacterium bifidum capsules and so on. It should be noted that intestinal probiotics must be staggered with antibiotics to avoid reducing the efficacy. If diarrhea occurs after taking the quadruple therapy, it is recommended to consult your doctor and change or stop the medication or treat the symptoms as appropriate. The medication should be used in accordance with medical advice.