After years of exploration, the principles of Chinese medicine in the treatment of malignant tumors can be roughly summarized into five, namely, the method of supporting the proper functioning of the body, activating blood circulation and removing blood stasis, clearing away heat and detoxifying toxins, softening and dispersing knots, and attacking toxins with toxins. Fostering the positive and consolidating the fundamental is the biggest feature of current Chinese medicine in the treatment of tumors. Clinical and experimental researches have proved that traditional Chinese medicine can slow down the development of tumor or inhibit the tumor mainly by improving the human body’s functional status and immune function rather than killing cancer cells directly. The specific applications of Chinese medicine in the comprehensive treatment of tumors are as follows: Chinese medicine is combined with surgical treatment: it can adjust the surgical damage, promote recovery and facilitate the patients to receive other treatments; it can assist the postoperative treatment in order to prevent recurrence and metastasis and prolong the survival time. Combination of Chinese medicine and radiotherapy: it can reduce the side effects of radiotherapy such as gastrointestinal reaction, bone marrow suppression and damage to normal tissues. Treating patients with advanced tumors with Chinese medicine mainly focuses on improving the quality of life, adjusting appetite and reducing pain.