Mitral and tricuspid regurgitation in the perimembranous part of the ventricular septal defect needs to be treated accordingly to the degree of regurgitation and the patient’s cardiac function. If the patient’s ventricular septal defect is not serious, only the mitral valve or tricuspid valve mild regurgitation, ventricular atrial diameter is normal, and the pulmonary artery pressure is normal, generally speaking, no treatment is needed. In daily life, patients should pay attention to monitoring blood pressure, and usually pay attention to preventing infective endocarditis and regular review. If the patient’s mitral tricuspid regurgitation is more serious, and the patient has the manifestation of cardiac insufficiency, the patient needs to take tolvaptan, furosemide and other drugs under the guidance of the doctor to enhance the cardiac function and reduce the cardiac load. If the ventricular septal defect is more serious and accompanied by severe mitral or tricuspid regurgitation, the patient may need to undergo prosthetic valve repair or valve replacement. Patients with ventricular septal defect with valve regurgitation need to be actively examined to determine the severity of the problem and be treated under the guidance of a doctor.