There is no clear scientific evidence on the time for low-grade squamous intraepithelial lesions to become cancerous, which may or may not be several years or more than 10 years. Low-grade squamous intraepithelial lesions may be caused by various pathogens that damage the cervical epithelium, and if the condition continues to worsen without standardized treatment, a few patients may develop cancer. However, there is no clear scientific evidence on the time of cancer development, which may be several years or decades. When low-grade squamous intraepithelial lesion of the cervix occurs, it is recommended to go to the hospital in time. If standardized treatment is carried out in time, the condition can usually be effectively controlled and may not become cancerous. To sum up, the time for low-grade squamous intraepithelial lesions to become cancerous needs to be judged according to the patient’s treatment, and cannot be generalized.