Ankle sprain and gout may both be accompanied by joint pain, but there are some differences in the nature, etiology, symptoms, treatment and other aspects. 1. Nature: ankle sprain is a joint soft tissue injury, gout is a metabolic rheumatologic immunological diseases. 2. Etiology: ankle sprains may be caused by improper exercise, inappropriate shoes, etc., leading to ligamentous tissue injury around the joint, no ligaments, tendons, etc.. Gout is related to abnormal purine metabolism in the body and impaired excretion of uric acid, leading to urate precipitation in the body. 3. Symptoms: ankle sprain will lead to soft tissue bleeding, pain and swelling, accompanied by red and purple bruising and other manifestations. Gout is often found in the auricles, joints, toes and other parts of the body, with symptoms such as redness, swelling, burning and pain, and the pain is severe, which may lead to joint deformity in severe cases. 4. Treatment: Ankle sprains require immediate rest and cold compresses, and the joint can be protected with a cast or brace. Gout needs to control uric acid level, apply colchicine tablets, allopurinol tablets, febuxostat tablets and other drugs to control the condition under the guidance of the doctor. If discomfort occurs, it is recommended to consult a doctor in time to avoid affecting normal life.