Bisoprolol fumarate irritates the stomach when taken for a long time. Clinically bisoprolol fumarate belongs to the beta receptor antagonist, after taking it can inhibit myocardial contractility and slow down the heart rate, so as to play the role of lowering blood pressure. Therefore, it is mainly used in the treatment of hypertension, coronary heart disease, angina pectoris and other diseases. Usually the drug may cause irritation to the gastrointestinal tract after taking it. Thus, nausea, vomiting, diarrhea, constipation and other discomforts may occur. It may also cause dizziness, headache, hearing impairment, fainting and other discomforts. And it is contraindicated for acute heart failure, cardiogenic shock, sinus block. For pregnant and lactating women, children should use the drug under medical supervision. If gastrointestinal discomfort occurs after taking Bisoprolol Fumarate for a long time, it is recommended to consult a doctor in time and adjust the medication under the guidance of a doctor.