Depression requires long-term maintenance of drug treatment, discontinuation of medication may be repeated symptoms, previous symptoms, such as insomnia, loss of interest, like to be alone, do not communicate with others, low self-esteem, slow thinking, memory loss, serious suicidal, self-injurious tendencies and behaviors, the symptoms of these diseases will be prone to recurrence. Antidepressants should not be stopped abruptly, which can cause withdrawal reactions, such as nausea, dizziness, bloating, diarrhea, dyspnea and other symptoms. In summary, it is not recommended that patients with depression stop taking their medication without authorization. Patients need to gradually adjust the drug dose, increase the drug, and finally stop the drug under the guidance of the doctor’s follow-up, all under the conditions allowed by the stabilization of the condition.