Thickening of intrahepatic light spots is considered to be a manifestation of liver fibrosis or cirrhosis. 1. Liver fibrosis: the thickening of intrahepatic light spots found during ultrasound examination of the liver indicates that the texture of the liver has changed and liver cell damage, followed by liver fibrosis. Such as viral hepatitis, drug hepatitis, alcoholic hepatitis and so on. 2. Cirrhosis: ultrasound of cirrhosis will also show thickening of intrahepatic spots, thickening of hepatic periosteum, increased echogenicity of hepatic parenchyma, roughness, accompanied by widening of portal vein diameter, and in severe cases, abdominal fluid accumulation, splenomegaly and other signs. In the case of thickening of intrahepatic spots, combined with relevant examinations, such as liver function, coagulation function and other indicators, we should comprehensively determine the cause of the patient’s disease, and carry out antiviral, hepatoprotective and symptomatic treatments according to the cause of the disease. Regular review is also necessary to facilitate the patient’s physical recovery.