There are three pathogenic markers of hepatitis B, surface antibodies, hepatitis B core antibodies and hepatitis B E antibodies, some of which will disappear and some of which will be present for life. In the case of hepatitis B surface antibody, which is a protective antibody for hepatitis B, produced by viral clearance after vaccination or hepatitis B virus, the titer of this antibody exists for a period of time and the titer may decrease or even disappear with time, so the titer of this antibody is monitored regularly. If it disappears, you need to get a new booster shot of hepatitis B vaccine. Hepatitis B core antibody is an antibody that appears after hepatitis B virus infection and exists for life. This antibody is not a protective antibody and cannot distinguish between present infection or previous infection. Hepatitis B E antibodies may disappear or may be present for a long time.