Urine protein quantification of 350mg/24h usually does not require a renal puncture biopsy procedure. Renal puncture biopsy is a puncture guided by ultrasound or CT to take one or several strips of renal tissue for pathological examination, which is an important means to clarify the etiology and pathology of many renal diseases, and is of great significance in the diagnosis, treatment and prognosis of renal diseases. Renal puncture biopsy can be performed for unexplained glomerular proteinuria with abnormal urinary sediment or persistent proteinuria >1.0g/24h; persistent or recurrent glomerulonephritis with or without proteinuria. It is recommended that patients with urine protein quantification of 350mg/24h should consult a regular hospital in time to find out the cause and follow the doctor’s instructions to choose the appropriate treatment.