Hands wrinkle easily when exposed to water because the oily sebaceous membrane of the hand skin is damaged and does not effectively prevent water from entering the stratum corneum. Causes of hand sebaceous membrane damage are dry skin, eczema dermatitis, tinea versicolor, palmoplantar keratosis and other diseases. 1. Dry hands: when the patient has insufficient water intake, in a dry and cold environment, excessive hand labor, etc. will make the skin of the hands become dry, the surface of the oil is reduced, which leads to the patient to touch the water easily wrinkled phenomenon. 2. Eczema dermatitis: when the hand due to a variety of factors produce eczema dermatitis, the skin will appear erythema, papules, blisters, vesicles, oozing, mossy and other manifestations, but also affects the surface of the skin sebaceous membrane function, which leads to the hand touching the water easily wrinkled. 3. Ringworm: an infectious disease caused by fungal infection of the skin on the hands, fungi act on the surface of the skin, which can lead to imbalance in the function of the skin surface, thus making the hands easily wrinkled when touching water. 4. Palmoplantar keratosis: due to hyperkeratosis of the palms of the hands, there will be skin thickening, dryness and flaking and other manifestations, which will also lead to the imbalance of water-oil on the surface of the skin, resulting in the above situation. It is recommended to go to the hospital to clarify the cause of the disease and treat the symptoms.