Congenital immunodeficiency diseases are diseases in which the function of the immune system is impaired due to defects in different genes, including antibody-deficiency diseases, human cellular immunity abnormalities, and mixed antibody-deficiency diseases. 1. Antibody deficiency diseases: including congenital hypogammaglobulinemia, selective IgA deficiency, acquired immunoglobulinemia, nephrotic syndrome and other diseases. 2. Human cellular immune abnormalities: including X-linked dysgammaglobulinemia, X-linked hyperimmunoglobulinemia M and other diseases. 3. Mixed antibody deficiency diseases: including severe combined immunodeficiency disease, immunodeficiency disease with thrombocytopenia and eczema, immunodeficiency disease with thrombocytopenia and eczema, immunodeficiency disease with ataxia and capillary dilatation, and other diseases. In the case of congenital immunodeficiency diseases, it is recommended to describe the detailed pathogenesis of the disease, complete immunodeficiency-related examinations, and promptly carry out active and effective treatment.