Hepatitis B 1, 3 and 5 positive refers to positive hepatitis B surface antigen, positive hepatitis B E antigen, and positive hepatitis B core antibody, which is commonly known as the major triplet. It generally means that the virus is more actively replicating and more infectious. For hepatitis B, the need for treatment depends on the liver function. If the liver function is normal and the five indicators of hepatitis B are major triple-positive, then the hepatitis B carrier does not need special treatment, regular review of liver function, hepatitis B DNA, liver ultrasound and the five indicators of hepatitis B will be fine. If the liver function is abnormal, the transaminase is more than twice the upper limit of the normal value, and the hepatitis B DNA is positive, this situation requires antiviral treatment.