Treatment of toothache with metronidazole is primarily for periodontal disease caused by anaerobic bacteria and usually needs to be taken for 7 days or longer. Toothache can be caused by a variety of diseases. If it is caused by deep caries, pulpitis or apical periodontitis, metronidazole treatment does not have a significant effect, and filling or root canal treatment is required. In cases of periodontitis and wisdom tooth pericoronitis, metronidazole can be used as an adjunct to local treatment. Metronidazole is an antibiotic that is effective for anaerobic infections that cause inflammation, such as the aforementioned periodontitis and pericoronitis. For patients with milder conditions, it usually needs to be taken for 7 days, provided that the indications are met, but patients with more severe conditions need to take it for a longer period of time. It is recommended that patients with toothache first go to the hospital to receive targeted treatment, and if you need to take metronidazole, you should also take it under the guidance of a doctor, not without authorization.