Vaginal ulcers may be caused by syphilis, genital herpes, fungal infections, etc. According to the cause of the disease, follow the doctor’s advice to choose the appropriate medication, such as penicillin, acyclovir and so on. 1. Syphilis: Syphilis is a sexually transmitted disease caused by the syphilis spirochete. Penicillin, as the drug of choice for syphilis, can be used for all periods of syphilis patients. 2. Genital herpes: genital herpes is a sexually transmitted disease mainly caused by herpes simplex virus infection, which can be treated with antiviral drugs such as acyclovir and valacyclovir. 3. Fungal infection: vulvar fungal infection caused by ulcers, can be used externally clotrimazole tablets or dakinin suppositories and other drugs, for unmarried women or unsuitable for local use of drugs, but also can choose fluconazole oral treatment. No matter which cause of vaginal ulcers, should be timely to clarify the cause of the disease, and related treatment, medication please follow the doctor’s instructions.