There are about 2.5 million Parkinson’s disease patients in China, accounting for half of the world’s patients, yet according to authoritative statistics, about 48% of Chinese patients are not aware that they have the disease, and most patients are not properly diagnosed and receive regular treatment for a long time. Parkinson’s disease itself is not a fatal disease and generally does not affect life expectancy. Modern medical technology, deep brain stimulation, is the biggest breakthrough in Parkinson’s disease treatment in recent years. It is performed through a brain pacemaker implanted in the body, which issues weak electrical impulses to stimulate the relevant nerve clusters in the brain that control movement, inhibiting the abnormal brain nerve signals that cause Parkinson’s disease symptoms, thus eliminating the symptoms of Parkinson’s disease and restoring the patient’s original mobility. Parkinson’s disease is a chronic disease, once the onset of symptoms will be with the patient for life, based on improving the quality of life of patients is particularly important. To improve the quality of life of patients, in addition to taking anti-Parkinson’s disease drugs and receiving deep brain electrical stimulation therapy, some rehabilitation or psychotherapy is also needed. So the treatment of Parkinson’s disease is not a single discipline can be competent, but rely on a full range of multidisciplinary teamwork, Parkinson’s disease treatment can not only rely on medical personnel, the family and society as a whole should join hands to give Parkinson’s disease patients more care and help. Nanjing Brain Hospital has a professional Parkinson’s disease and movement disorders treatment team composed of neurology, neurosurgery, neuropsychology, neurophysiology, rehabilitation, neuroimaging and other multi-disciplinary experts. After the middle and late stages of Parkinson’s disease, many patients will inevitably experience serious complications such as diminished drug efficacy, symptom fluctuations and allodynia, which some patients are unable to resolve through the aforementioned drug adjustments, at which time, appropriate surgical procedures will be a good option. There are three types of surgical procedures, the first one is destructive surgery and the second one is deep brain stimulation or DBS treatment. Destructive surgery is rarely tried in Europe and the United States due to its heavier adverse effects, such as swallowing, speech and balance dysfunction, and its poor long-term outcome after 1 to 2 years. Neural stem cell transplantation is still in animal experimental stage and it may take a long time to be used in the clinic. At this stage, DBS is the latest advancement in the treatment of PD and has largely replaced disfiguring surgery in developed countries. DBS is the use of brain stereotactic techniques to implant electrodes at a specific location in the brain, such as the nucleus accumbens. dBS can improve symptoms in patients with Parkinson’s disease, probably because it stimulates the release of local inhibitory neurotransmitters, produces a functional disruption similar to that in the target area, raises the threshold of excitatory potentials, and regulates neuronal activity at the same time. the pulsatile firing stimulation of DBS produces a regular and stable firing pattern Corrects abnormal excitation and irregular firing of the patient’s basal ganglia loop neurons. It can improve the motor symptoms of patients, including the midline symptoms such as “difficult start” and “stiff gait”, and it can also reduce the dosage of levodopa, and has good effect on the adverse effects of levodopa, such as allodynia and painful spasm. Surgery is mainly indicated for the following patients: 1, typical Parkinson’s disease, which had been effective for levodopa preparations. 2.After systematic drug treatment, symptoms can no longer be controlled or comorbidities of dyskinesia appear, and adjustment of drugs cannot improve. 3.No severe cognitive and mental impairment and severe brain atrophy. 4. The patient has been treated with levodopa for at least 5 years after diagnosis.