Foot big toe pain can be caused by the following reasons: first, gout, gout is the most common cause of pain in the big toe, severe cases can be accompanied by local redness and swelling, elevated skin temperature, and even the formation of gout stone. At this time, we should pay attention to check the blood uric acid and physical examination for diagnosis, and give uric acid-lowering drug treatment at an early stage. Secondly, it may be caused by infectious diseases, such as bacterial infection and tuberculosis infection of the bone and soft tissues of the big toe, which can also appear as pain in the big toe. Third, tumors, if there are tumors growing in the bone and soft tissues of the big toe, it can lead to pain in the big toe, and there can be very obvious limitation of movement when walking. At this time, it is necessary to check the CT line film and MRI examination of the big toe for diagnosis and early treatment. Fourth, pain in the big toe of the foot can also be caused by trauma or fatigue fracture, which should be diagnosed based on the patient’s history of trauma.