Cefradin and Cefixime can not simply say which one is good, the former antibacterial spectrum is broader than the latter, the latter is more targeted than the former, the former in mild to moderate infections in the application of the latter, the latter in severe infections in the application of the former, the former on the Gram-positive cocci antibacterial, the latter on the Gram-negative bacilli antibacterial, the patient’s condition is the best for the patient’s condition. 1. Cefradin has a broad antibacterial spectrum, for drug-resistant S. aureus and a variety of broad-spectrum antibiotic-resistant bacilli with a strong bactericidal effect, cefixime is a narrower antibacterial spectrum, but more targeted, for the diseases caused by sensitive bacteria have a strong antibacterial effect. 2. Cefradine is mainly used in mild to moderate respiratory tract, urinary tract, skin and soft tissue infections, such as pyelonephritis, bronchitis, pneumonia, etc. In addition to the above indications, cefixime is also used in the severe infections caused by sensitive bacteria, such as bacteremia, septicemia, osteomyelitis. 3. Cefradine for gram-positive cocci antibacterial effect is stronger than cefixime, for gram-negative bacilli cefixime is stronger than cefradine. The adverse reactions and contraindications of the two are allergy, nausea, vomiting, abdominal pain, diarrhea, etc.; cephalosporin allergy is prohibited. In summary, the two have their own strengths, the use of their own conditions and under the guidance of a doctor to choose reasonably.