Feeling pain during azithromycin injection may be caused by irritation of the medicine, infusion leakage, phlebitis, drug allergy and other reasons. Azithromycin injection is mainly used for infections caused by sensitive pathogenic strains: community-acquired pneumonia caused by Chlamydia pneumoniae, Haemophilus influenzae, Legionella pneumophila, Cattamoeba, Staphylococcus aureus, and Streptococcus pneumoniae; and pelvic inflammatory disease caused by Chlamydia trachomatis, Diplococcus gonorrhoeae, and Mycoplasma hominis. Patients may feel pain when injecting azithromycin. The common causes are the irritation of blood vessels caused by the drug itself and its excipients, or phlebitis caused by intravenous injection. If the patient is allergic to azithromycin, it may also cause pain during infusion. In addition, leakage of the solution due to improper handling or excessive movement of the injection site may also cause pain. Common adverse reactions to azithromycin injection include: gastrointestinal reactions, such as diarrhea and abdominal pain, nausea and vomiting, loose stools, etc.; local reactions, such as pain and inflammation at the injection site, etc.; skin allergic reactions, such as rash, itching, etc.; and others, such as anorexia, dizziness, dyspnea and other symptoms. If serious allergic reactions, such as angioneurotic edema, skin reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis and other symptoms occur during the use of the drug, please stop using the drug immediately and seek medical attention. In addition, patients allergic to azithromycin, erythromycin or other macrolides are prohibited; caution should be exercised in hepatic insufficiency; caution should be exercised in ethanol allergy; caution should be exercised in pregnant women and lactating mothers; the application of children under 16 years of age and elderly patients is unclear. If you need to use azithromycin injection, please consult a professional doctor, follow the doctor’s instructions for standardized treatment, not blindly use the drug.