Babies always cry in the middle of the night, there may be physiological or pathological factors, physiological factors such as feeling cold, hot, hungry or neglected; pathological factors such as intestinal flatulence, intestinal colic or even tuberculosis and other conditions. 1. Physiological factors: babies will cry at night when they feel cold, hot and stuffy, or hungry; similarly, babies will also cry when they wake up at night and have not been pacified for a long time, and they will feel insecure or neglected. 2. Pathological factors: the development of the baby’s digestive system is not perfect, easy to intestinal flatulence, intestinal colic phenomenon, so that the baby feels uncomfortable or pain, there will be crying phenomenon; in addition, suffering from bone tuberculosis of the baby at night due to bone pain, there will also be the symptom of night crying. Baby sleep in the middle of the night always cry, there may be other reasons, it is recommended to go to the hospital in a timely manner, improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment.