If you cannot urinate and have pain in the urethra, it is recommended to go to the hospital for relevant examination and give symptomatic treatment. 1. If the difficulty in urination is due to acute infection with pain and mucosal edema in the urethra, it is recommended to give anti-infection treatment. If you are a male with prostatic hyperplasia combined with infection, and you are unable to urinate and have pain in the urethra, it is recommended that you have an indwelling catheter, a suprapubic cystocentesis fistula, and temporarily leave the urinary catheter in place first to drain the urine out of the body. This will help to reduce the patient’s pain and the feeling of not being able to urinate. The latter stage of anti-infection treatment and symptomatic treatment of prostatic hyperplasia, such as oral tamsulosin hydrochloride extended-release capsule, 1 capsule, 1 time a day, and oral levofloxacin hydrochloride capsule, 1 capsule, 3 times a day, after 3-7 days of continuous use, intermittent clamping of the urethral tube to train bladder function, and then remove the urethral tube, and observe whether the difficulty in urination is relieved and whether the pain in the urethra disappears.