Acid reflux with heartburn may be caused by chronic gastritis, gastroesophageal reflux, peptic ulcer and so on. 1. Chronic gastritis: this disease is mainly related to the infection of Helicobacter pylori, drugs, autoimmune and other factors, resulting in patients with acid reflux with heartburn, accompanied by middle and upper abdominal discomfort, fullness, nausea and other symptoms. 2. Gastroesophageal reflux (GERD): If affected by food, medication, long-term alcohol consumption, smoking and other factors, patients will experience acid reflux with heartburn, accompanied by chest pain, sore throat, chronic cough and other symptoms. 3. Peptic ulcer: acid reflux with heartburn may be caused by peptic ulcer, mainly caused by one or more invasive damage factors to the mucous membrane damage over the mucous membrane to resist damage and their own repair ability. Typical symptoms are abdominal pain after meals or on an empty stomach, and may be accompanied by acid reflux, heartburn and bloating and other discomforts. It is recommended that patients go to the hospital in time, under the diagnosis of the doctor, according to the patient’s condition, relevant examinations, according to the specific results of the examination, to take targeted treatment.