Small granules on the hands and feet, accompanied by itching, are considered to be due to herpes sweat, eczema, hand, foot and mouth disease and other factors. 1. Sweat herpes: this is a blistering disease that occurs symmetrically on the hands or feet, and is considered to be related to allergies, dermatophyte infections, and psychiatric factors, and not only will there be blistering symptoms, but will also be accompanied by intense itching, tingling, and burning sensation. 2. Eczema: small particles on the hands and feet, accompanied by itching, may be due to eczema, which is a dermatitis that occurs on the hands and feet, can be triggered or aggravated by external stimuli, allergies, mental disorders and other factors. 3. Hand, foot and mouth disease: when the patient has hand, foot and mouth disease, can also cause scattered blisters on the hands, feet and mouth area, this is due to enterovirus infection, can be induced through the digestive tract, respiratory tract, as well as close contact with the pathway. Itchy hands and feet long small particles, it is recommended that timely consultation, with the doctor to improve the examination, clear specific causes, and then standardized treatment.