Glimepiride and metformin are two different mechanisms of action, there is no good or bad, depending on which drug is more suitable, glimepiride is a sulfonylurea hypoglycemic drugs, the main mechanism of action is to stimulate the pancreas to secrete insulin, the premise of application is that the body still has a certain number of functional B cells, practical for newly diagnosed type 2 diabetes non-obese patients, once a day can be taken. However, it cannot be used in patients with type 1 diabetes and type 2 diabetes with poor pancreatic islet function, and it cannot be applied to pregnant and lactating women, and the main adverse effect is hypoglycemia. Metformin is a hypoglycemic drug of biguanide class, the main mechanism of action is to inhibit liver output of glucose and improve insulin sensitivity, mainly for type 2 diabetes obese, there is insulin resistance, the main adverse reactions are gastrointestinal reactions, so choose the appropriate hypoglycemic drug according to your own situation.